Cobicistat Impurity 15

Cobicistat Impurity 15 - Names and Identifiers

Name	N-[(1R,4R)-4-Amino-5-phenyl-1-(phenylmethyl)pentyl]carbamic acid 5-thiazolylmethyl ester hydrochloride
Synonyms	Cobicistat Impurity 15 Cobicistat intermediate N-[(1R,4R)-4-Amino-5-phenyl-1-(phenylmethyl)pentyl]carbamic ... 5-Thiazolylmethyl [(2R,5R)-5-Amino-1,6-diphenyl-2-hexyl]carbamate Hydrochloride thiazol-5-ylMethyl (2R,5R)-5-aMino-1,6-diphenylhexan-2-ylcarbaMate hydrochloride N-[(1R,4R)-4-Amino-5-phenyl-1-(phenylmethyl)pentyl]carbamic acid 5-thiazolylmethyl ester hydrochloride FAVORITES COMPARE N-[(1R,4R)-4-AMINO-5-PHENYL-1-(PHENYLMETHYL)PENTYL]CARBAMIC ACID 5-THIAZOLYLMETHYL ESTER HYDROCHLORIDE 1247119-33-0
CAS	1247119-33-0
EINECS	700-848-8

Cobicistat Impurity 15 - Physico-chemical Properties

Molecular Formula	C23H28ClN3O2S
Molar Mass	446.01
Storage Condition	2-8℃

Cobicistat Impurity 15 - Introduction

N-[(1R,4R)-4-amino-5-phenyl-1-benzylpentyl] carbamic acid 5-thiazolylmethyl ester hydrochloride (abbreviated as "NBS") is an organic compound with the following properties:

1. Appearance: NBS is white or light yellow solid.
2. Solubility: NBS is easily soluble in water and organic solvents such as alcohol and ether.
3. Chemical properties: NBS is an oxidizing reagent, which is often used as a reagent for selectively oxidizing bromide to a good leaving group in the reaction.

The main uses of NBS are as follows:
1. Bromination reagent: NBS is often used as a local oxidant, which can selectively convert carbon-hydrogen bonds into carbon-bromine bonds.
2. light starting agent: NBS can be used as a light starting agent in organic synthesis, through the light initiated reaction.
3. Reagents: NBS is commonly used in organic synthesis reactions, such as halogenated reagents, nucleophilic reagents, organic synthesis intermediates and a variety of activators.

The preparation methods of NBS mainly include the following:
1. p-Bromobenzyl alcohol and glutarimide are reacted under acidic conditions to obtain NBS.
2. N-bromobenzimide and glutarimide are reacted under alkaline conditions to obtain NBS.

Regarding the safety information of NBS, the following matters need to be paid attention:
1. NBS is an organic compound with certain toxicity, so it is necessary to wear appropriate personal protective equipment during operation.
2. Avoid contact with skin, and wear laboratory gloves and goggles during operation.
3. Avoid inhaling dust or gas, and ensure that the operation is carried out in a well-ventilated environment.
4. avoid contact with strong oxidants, strong acids and other substances to avoid dangerous reactions.
5. storage should be sealed, away from fire, high temperature and flammable materials.

Last Update：2024-04-09 20:49:11